Transfer Factor and Clinical Applications

by Steven J. Bock, MD Reprinted with Permission from the International Journal of Integrative Medicine
The immune system is amazingly complex. Fortunately, nature gives neonates a little help. We are realizing the importance of breast-feeding and immune competency. In this increasingly dangerous world, we are being assaulted by pathogen after pathogen. Our immune systems are faltering. Transfer factor (TF), the premier immune factor in colostrum, can be a vital part of our armamentarium. Transfer factor trains and continually educates the immune system.
H.S. Lawrence discovered transfer factor in 1949, when he demonstrated that an immune fraction of a person’s white blood cells was able to transfer immunity in a nonsensitized individual.
Transfer factors are small molecules of 3,500-6,000 kDa molecular weight, consisting of oligoribonucleotides attached to a peptide molecule. In the past, they were derived from dialyzed white blood cells (WBC), but now can be purified from bovine colostrum. They are produced by T-lymphocytes and can transfer the ability to recognize a pathogen to cells that have not been in contact with the pathogen (memory function). They also heighten the immune system’s ability to react (increased reactivity or inducer function) to pathogens. Transfer factor probably produces a trigger for T-cell recognition of antigen. On the other hand, it may act as a gene product that assists in antigen presentation to other T-cells.(1)
This inducer fraction of transfer factor links the immune cells with an antigen-binding site, thereby increasing their reactivity to an antigenic stimulus. The suppressor fraction blocks the response of the T-cells,(2) and signals a down regulation of the immune response. This is useful in allergic or autoimmune conditions.
Role of TH1, TH2
Before one can understand the usefulness of transfer factor, it is helpful to have an understanding of the TH1 helper/TH2 helper paradigm. T helper lymphocytes develop along two lines of cell populations. TH1 cells, which modulate cell-mediated immunity, produce the cytokines: IL-2, IFN-gamma, and TNF-alpha. TH2 cells, which modulate humoral immunity, or antibody production, produce IL-4, IL-5, IL-6, IL-10, and IL-13. Once you’re familiar with the particular TH1/TH2 predominant phenotypes in a patient, you can more easily identify certain constellations of diseases or conditions, and tailor your therapies.
Cell-mediated or TH1 helper responses are important in the body’s ability to defend itself against viruses, fungi, parasites, cancer, and intracellular organisms. Cell-mediated immunity can be tested by: 1.
Skin tests–delayed hypersensitivity skin testing;
Response to non-specific mitogens, such as phytohemagglutinin (PHA), concavalina, or pokeweed mitogens;
Response to specific mitogens, such as diptheria, tetanus, or candida;
Response to alloantigens—mixed lymphocyte reaction;


February 10, 2008 - Posted by | 4LIFE, imun sisitem, kanser, KESIHATAN, SAKIT

No comments yet.

Leave a Reply

Please log in using one of these methods to post your comment: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: